Galoxin Plus Drug Interactions

Otherwise harmless doses of Acetaminophen may cause liver damage if taken together with drugs leading to enzyme induction such as certain hypnotics and anti-epileptics (e.g. Gluthetimide, Phenobarbital, Phenytoin, Carbamazepine) as well as Rifampicin.
The same applies to potentially hepatotoxic substances and alcohol abuse.
Combination with Chloramphenicol can prolong the half life of Chloramphenicol with the risk of increased toxicity.
The clinical relevance of interactions between Acetaminophen and Warfarin as well as coumarin derivates cannot yet be assessed. Therefore, longterm use of Acetaminophen in patients being treated with anti-coagulants is only advisable under medical supervision.
Concomitant use of Acetaminophen and Zidovudine (AZT or Retovir) enhances the tendency towards reducing leucocytes (neutropenia). Therefore, this product should only be taken together with Zidovudine following medical advice.
Intake of Probenecid inhibits the binding of Acetaminophen to Glucoronic Acid, thereby reducing Acetaminophen clearance roughly by a factor of 2. The Acetaminophen dose should therefore be reduced during concurrent administration with Probenecid.
Cholestyramine reduces the absorption of Acetaminophen.
Intake of Acetaminophen may impact the lab determination of uric acid by phosphotungstic acid and of blood glucose by glucose oxidase-peroxidase.
The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants, antihistamines, antipsychotics, Quinidine, Amantadine, Disopyramide and other anti-cholinergics (e.g. Tiotropium, Ipratropium, Atropine-like compounds) may be intensified by this product.
Concomitant treatment with dopamine antagonist such as Metoclopramide Hydrochloride may result in diminution of the effects of both drugs on the gastrointestinal tract.
The tachycardic effects of beta-adrenergic agents may be enhanced by this product.
For oral applications in addition: Where gastric emptying is slowed down, as for instance with Propantheline, the absorption rate of Acetaminophen may be reduced with the results that onset of action delayed. Acceleration of gastric emptying, e.g. after administration of Metoclopramide, leads to an increase in the absorption rate of Acetaminophen.